Extract L-Asparaginase by column chromatography;

柱層析法提取門冬酰胺酶

The crude L-asparaginase was purified by ion exchange chromatography of DEAE-Sephadex A-50.

采用 DEAE- Sephadex A- 5 0層析純化門冬酰胺酶 ,HPL C檢測(cè)結(jié)果表明 ,產(chǎn)品純度和收率均有提

Hyperglycemia induced by asparaginase and dexamethasone:2 case reports;

門冬酰胺酶合用地塞米松致高血糖2例

Cerebrospinal fluid asparagine concentrations after high-dose of L-asparaginase in childhood with acute lymphoblastic leukemia;

急性淋巴細(xì)胞白血病患兒大劑量靜脈滴注門冬酰胺酶治療后腦脊液門冬酰胺濃度

Methods :Gene fragments encoding a truncated asparaginasefragment mutant,native C-peptide,a hinge fragment of human IgG1,an extra acid-labile dipeptide and a basic-amino-acid-riched octopeptide were introduced in turn into plasmid pET28a.

方法:將編碼截短的門冬酰胺酶突變體(ansB-C),天然C肽,人IgG1鉸鏈區(qū)(hinge),額外的酸敏感二肽(DP)以及富含堿性氨基酸的8肽(KRKRKKSR)的核苷酸序列依次分別插入pET28a載體中,構(gòu)建表達(dá)載體pEDCC。

Construction and Enzyme-activity Assessment of L-Asparaginase Mutants;

L-門冬酰胺酶突變體的構(gòu)建及其活性測(cè)定(英文)

Effects of recombinant L-asparaginase proliposomes on the growth of HL-60 cells;

重組L-門冬酰胺酶前體脂質(zhì)體對(duì)HL-60細(xì)胞生長(zhǎng)的影響

Combination of large dose of methotrexate and L-asparaginase in treatment of adult patients with refractory or recurrent acute lymphoblastic leukemia;

大劑量甲氨蝶呤聯(lián)合L-門冬酰胺酶治療成人難治或復(fù)發(fā)急性淋巴細(xì)胞白血病

Studies on Immobilized L-asparaginase Based on Polyacrylamide and PEG;

聚丙烯酰胺-聚乙二醇對(duì)L-天門冬酰胺酶的包埋研究

Effect of β-cyclodextrin on the stability of L-asparaginase;

β-環(huán)糊精對(duì)L-天門冬酰胺酶的穩(wěn)定作用

The research advance on reducing adverse effects of L-asparaginase;

降低L-天門冬酰胺酶毒副作用的研究進(jìn)展

Soluble and functional expression of L asparaginase in Escherichia coli;

L-天門冬酰胺酶的可溶性表達(dá)研究

A combination of guanidine HCl and Triton X 100 can release L asparaginase (EC 3.

研究了用鹽酸胍和TritonX 10 0處理ATCCEscherichiacoli 1130 3細(xì)胞 ,使細(xì)胞內(nèi)的L-天門冬酰胺酶 (EC 3。

coli L asparaginase was modified by N,O carboxymethyl chitosan.

采用水溶性殼聚糖對(duì) L-天門冬酰胺酶進(jìn)行化學(xué)修飾 ,修飾后的酶活回收率高達(dá) 70 % ,修飾酶的比活為每毫克蛋白質(zhì) 1 2 1 。

Studies on Immobilized L-asparaginase Based on Polyacrylamide/N,N'-methylenebisacrylamide;

聚丙烯酰胺/N,N'-亞甲基雙丙烯酰胺固定化L-天門冬酰胺酶的研究

Side effects of L-asparaginase in different administrating use.

左旋門冬酰胺酶不同用法副作用的觀察

Nursing care of a patient with severe acute pancreatitis induced by L-asparaginase

1例左旋門冬酰胺酶誘發(fā)重癥急性胰腺炎病人的護(hù)理

Adverse Reaction of Childhood Patients With Malignant Tumor Treated by L-asparaginase

左旋門冬酰胺酶治療小兒惡性腫瘤毒副反應(yīng)的觀察

Preventing the adverse effect of L-asparaginase during the chemotherapy in children with malignant tumors

左旋門冬酰胺酶治療兒童惡性腫瘤的毒副作用及其防治研究

Studies on the Preparation, Purification and Identification of N-terminal Site-Specific Mono-PEGylation of L-Asparaginase;

N-端聚乙二醇化L-門冬酰胺酶的制備、純化及鑒定研究

Adverse Influense of Glycometabolism Caused by L-asParaginase in Children Used In Acute LymPhoblastic Leukemia

兒童淋巴細(xì)胞白血病應(yīng)用左旋門冬酰胺酶對(duì)糖代謝的影響

Objective To investigate care of the patients with acute leukemia who had complication of central nerve system because of administration of L-ASP.

目的 :探討急性白血病病人應(yīng)用左旋門冬酰胺酶后出現(xiàn)中樞神經(jīng)系統(tǒng)并發(fā)癥的護(hù)理方法。

THE TOXICITY OF L-ASPARAGINASE TO PANCREAS IN TREATING CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

左旋門冬酰胺酶治療兒童急性淋巴細(xì)胞性白血病的胰腺毒副作用觀察

Side Effects of L-asparaginase during Therapies for Remission Induction and Maintenance in Children with Acute Lymphocytic Leukemia

兒童急性淋巴細(xì)胞白血病誘導(dǎo)緩解及維持期治療中左旋門冬酰胺酶副作用的比較

The amide nitrogen of glutamine or asparagine functions more effectively than ammonia.

谷酰胺或天門冬酰胺的酰胺氮作用較氨更有效。

Aspartate is readily converted to asparagine.

天門冬氨酸易于轉(zhuǎn)變成天門冬酰胺。

Cyanide can serve as precursor for the amide nitrogen of asparagine.

氰化物可以作一個(gè)天門冬酰胺的酰胺氮前體。

Recent Advances in Clinical Studies on PEG-L-asparaginase

PEG-L-天冬酰胺酶的臨床研究近況

Studies on the Silk Sericin Protein as a Support of Immobilized L-asparaginase;

以絲膠蛋白為載體的固定化L-天冬酰胺酶研究

Cell Culture and the Fermentation System of Asparagus;

石刁柏細(xì)胞培養(yǎng)及其L-天冬酰胺酶發(fā)酵

Preparation and Identification of Anti-ASNS Monoclonal Antibody;

抗人天冬酰胺合成酶單克隆抗體的制備與鑒定

Construction and Application of Screening Model of Asparagine Synthetase B in Vitro

天冬酰胺合成酶B體外篩選模型的構(gòu)建與應(yīng)用